She won best pop vocal album with her record Sweetener.
Writing on Instagram, she said her first Grammy win was “wild and beautiful” but confirmed she would not be attending the ceremony.
“I know I’m not there tonight (trust, I tried and still truly wished it had worked out tbh) and I know I said I try not to put too much weight into these things…this is wild and beautiful. Thank you so much. I love u (sic),” she wrote.
On Friday, the singer accused the organiser of the Grammys of lying about her reasons for withdrawing from performing at the ceremony.
The singer posted several tweets explaining her reasons for not attending the show after Grammys producer Ken Ehrlich said her absence was down to not being able to organise her set in time.
Grande denied this, saying she could “pull together a performance overnight”, and instead said Ehrlich had “stifled” her creativity.
Other winners of the night included London-born singer Ella Mai, who won best R&B song for her US number one hit Boo’d Up and Beyonce and Jay-Z, listed as The Carters, who won best urban contemporary album for Everything Is Love.
Childish Gambino won best music video for The Is America and a collaboration between Sting and Shaggy saw them win best reggae album for 44/876.
The late Soundgarden singer Chris Cornell, who died from suicide in 2017 aged 52, won a posthumous Grammy for best rock performance for the song When Bad Does Good. His children accepted the award on his behalf.
A second controversy around the awards broke in January when Grammy organisers were forced to deny that a “leaked” list of winners posted on social media ahead of the awards were genuine.