The Hanseatic Nature had planned to make a stop in Guernsey after visiting Honfleur in France.
The ship has been unable visit the Bailiwick 'due to weather' according to Guernsey Harbours.
The vessel and its 230 passengers were due to arrive in the island at 8am today (7 April).
It is now sailing straight to Coruna in Spain instead.
Two major lines, MSC and Princess, are not using Guernsey this year, citing issues with getting passengers ashore.
It follows the Guernsey Tourism Management Board's prediction that the number of cruise liner visits will decline in the coming years.
The Silver Endeavour is the next cruise ship in the 2024 calendar to stop-off in Guernsey. It is planning to arrive in the island at 2pm on Monday 8 April.

Guernsey's airline reacts to reduced demand because of Iran attacks
Survey reveals scale of dissatisfaction with off-island travel
Two youngsters questioned by Guernsey Police after fire at Leale's Yard
Prominent Guernsey consultant cardiologist suspended by the GMC
Guernsey FC features on Premier League social media
Law banning under-18s enter Guernsey vape shops labelled 'hypocritical'
Channel Island iPhone users struggle with age verification update
Eleven candidates for Guernsey's first island-wide by election