Quechua (Chui) and Bahia are packing their bags to leave the island after a decade to move to Merseyside.
The Andean Bears are moving to Knowsley Safari in Prescot to join a special breeding programme.
A captive population of spectacled bears, created by numerous zoos working together, aims to save the species.
Georgia Gotts, Team Leader of Mammals at the Zoo, says it is always sad to say goodbye to a much-loved species.
"During their time in Jersey, they welcomed their son, Raymi, who was the first cub born at the zoo in over 20 years.
"Raymi has since gone on to have three cubs of his own at Givskud Zoo, which has given this threatened species a much-needed lifeline."
The pair who came to Jersey in 2013 will say goodbye to the island in November as part of the move, which has been in the books since the start of the year.
Chui and Bahia's new enclosure at the safari park is more extensive, giving the bears extra space to roam and explore.
To celebrate 10 years in the island, Jersey Zoo is holding a 'Bye Bye Bears' weekend on 14 and 15 October.
Islanders can join in on teddy bear picnics, keeper talks, themed activity trails and face painting.
However, this is not the end of bears calling Jersey home.
Over the next few months, Chui and Bahia's old enclosure will be transformed and adapted to welcome more South American animals.
They will be coming over as part of Durrell's conservation work in Brazil's Atlantic Forest.
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